Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 18 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc L-Methionine Sulfate)
15 mg
136%
Copper (as Gluconate)
1 mg
111%
Top Medical Research Studies
7
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Read More
9
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
8
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
Most Useful Reviews
9
Relieved fatigue symptoms
105 people found this helpful
Excellent! I hesitated to buy this zinc for ages, but after my mother’s passing, I felt extreme fatigue and depression. This supplement has gradually helped to improve my well-being.
Read More
9
Improved symptoms
5 people found this helpful
After more than two months of taking Reishi mushroom and maintaining a healthy diet, I've noticed a significant improvement in my chronic fatigue syndrome symptoms. My periods are regular, and excessive hair growth has decreased. The capsules are small, easy to swallow, and of high quality.
Read More
9
Fatigue relief
1 people found this helpful
I discovered zinc deficiency after unexplained back pain and noticed that fatigue I attributed to age was actually due to this deficiency. After taking this zinc supplement, my chronic fatigue syndrome has gradually improved.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
- All Researches
9
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
Read More
8
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
8
Beta-glucan improves cognitive fatigue
We conducted a study to explore the potential benefits of beta-glucan supplementation in individuals suffering from chronic fatigue syndrome (ME/CFS). Over 36 weeks, we engaged 65 patients in a randomized, double-blind trial where they received either a daily combination of beta-glucan, vitamin D3, vitamin B6, and zinc, or a placebo that contained only microcrystalline cellulose. This approach allowed us to assess the overall impact of this nutritional supplement on fatigue, sleep quality, anxiety, and cognitive performance.
Our findings were particularly encouraging regarding cognitive fatigue; those who received the beta-glucan supplementation showed a significant improvement in cognitive fatigue symptoms over the study period. While zinc was included in the supplement mix, it makes it challenging to pinpoint its isolated contribution to the benefits observed. Therefore, we caution that any conclusions about zinc’s effects on chronic fatigue syndrome should be drawn with care.
This research provides valuable insights into how yeast-derived beta-glucan might serve as a helpful supplement for patients facing cognitive challenges associated with ME/CFS. Moving forward, further investigations are needed to confirm these outcomes and to better understand the immunometabolic mechanisms at play.
Our findings were particularly encouraging regarding cognitive fatigue; those who received the beta-glucan supplementation showed a significant improvement in cognitive fatigue symptoms over the study period. While zinc was included in the supplement mix, it makes it challenging to pinpoint its isolated contribution to the benefits observed. Therefore, we caution that any conclusions about zinc’s effects on chronic fatigue syndrome should be drawn with care.
This research provides valuable insights into how yeast-derived beta-glucan might serve as a helpful supplement for patients facing cognitive challenges associated with ME/CFS. Moving forward, further investigations are needed to confirm these outcomes and to better understand the immunometabolic mechanisms at play.
Read More
8
Zinc's limited role in fatigue relief
We conducted a study to explore how oral supplementation of melatonin combined with zinc affects fatigue in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The trial lasted 16 weeks, involved 50 participants, and was designed as a randomized, double-blind, placebo-controlled study. Patients were divided to receive either melatonin with zinc or a placebo daily.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieved fatigue symptoms
105 people found this helpful
Excellent! I hesitated to buy this zinc for ages, but after my mother’s passing, I felt extreme fatigue and depression. This supplement has gradually helped to improve my well-being.
Read More
9
Improved symptoms
5 people found this helpful
After more than two months of taking Reishi mushroom and maintaining a healthy diet, I've noticed a significant improvement in my chronic fatigue syndrome symptoms. My periods are regular, and excessive hair growth has decreased. The capsules are small, easy to swallow, and of high quality.
Read More
9
Fatigue relief
1 people found this helpful
I discovered zinc deficiency after unexplained back pain and noticed that fatigue I attributed to age was actually due to this deficiency. After taking this zinc supplement, my chronic fatigue syndrome has gradually improved.
Read More
9
Enhanced well-being
Since taking Zinc Balance for a month, my well-being has significantly improved. My chronic fatigue syndrome symptoms have reduced, and I feel more energetic. The capsules are simple to swallow, and although pricey, the results are worth it.
Read More
7.5
Effective for healing
4 people found this helpful
If you're dealing with chronic fatigue syndrome or slow-healing wounds, zinc is essential! This trace mineral has various health benefits, including immune support and skin healing. I take one capsule daily and feel well, with no side effects!
Read More
Frequently Asked Questions
9
Enhanced well-being
Since taking Zinc Balance for a month, my well-being has significantly improved. My chronic fatigue syndrome symptoms have reduced, and I feel more energetic. The capsules are simple to swallow, and although pricey, the results are worth it.
9
Improved symptoms
5 people found this helpful
After more than two months of taking Reishi mushroom and maintaining a healthy diet, I've noticed a significant improvement in my chronic fatigue syndrome symptoms. My periods are regular, and excessive hair growth has decreased. The capsules are small, easy to swallow, and of high quality.
7.5
Stronger immunity
I've recently started taking zinc, and it's markedly improved my chronic fatigue syndrome, as my skin condition and energy levels have improved, plus I feel more cheerful. The tablets are easy to swallow.
6
Alleviated fatigue
1 people found this helpful
These non-GMO zinc and copper tablets are easy to take. After months of use, I’ve noticed a reduction in my afternoon mental fatigue. A single tablet after breakfast suffices for my daily needs.
6
Supports immunity
1 people found this helpful
Zinc plays a critical role in over 300 bodily functions, including the immune system and energy levels. People with chronic fatigue syndrome often face deficiencies. This supplement offers a beneficial dosage of zinc and copper for overall health and energy.
7.5
Less hair loss
2 people found this helpful
Excellent! I bought this zinc to address increased hair loss, suspecting a deficiency. These small, easy-to-swallow capsules have seemingly reduced my hair loss and improved my chronic fatigue syndrome symptoms.
6
Improved immunity
10 people found this helpful
I initially bought this zinc for its benefits during a sale, but I was mistaken. Zinc is vital for insulin synthesis and immunity. I regret not choosing a monopreparation earlier, as copper interferes with zinc absorption. I still take it now but plan to switch to a better form for my chronic fatigue syndrome.
9
Fatigue relief
1 people found this helpful
I discovered zinc deficiency after unexplained back pain and noticed that fatigue I attributed to age was actually due to this deficiency. After taking this zinc supplement, my chronic fatigue syndrome has gradually improved.
7.5
Effective for healing
4 people found this helpful
If you're dealing with chronic fatigue syndrome or slow-healing wounds, zinc is essential! This trace mineral has various health benefits, including immune support and skin healing. I take one capsule daily and feel well, with no side effects!
7
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
8
Zinc's limited role in fatigue relief
We conducted a study to explore how oral supplementation of melatonin combined with zinc affects fatigue in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The trial lasted 16 weeks, involved 50 participants, and was designed as a randomized, double-blind, placebo-controlled study. Patients were divided to receive either melatonin with zinc or a placebo daily.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
References
- Ranisavljev M, Stajer V, Todorovic N, Ostojic J, Cvejic JH, et al. The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial. Eur J Nutr. 2024;64:28. doi:10.1007/s00394-024-03546-0
- Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, et al. Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17040463
- Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15214504
- Imai K, Yamano T, Nishi S, Nishi R, Nishi T, et al. Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment. Viruses. 2022;14. doi:10.3390/v14050907
- Castro-Marrero J, Zaragozá MC, López-Vílchez I, Galmés JL, Cordobilla B, et al. Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants (Basel). 2021;10. doi:10.3390/antiox10071010
- Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008;29:902.
- Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.
